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High-fat diet in pregnancy may up breast cancer risk


High-fat diet in pregnancy may up breast cancer risk
UPI.com

Feeding pregnant female mice a diet high in fat derived from common corn oil resulted in genetic changes that substantially increased the susceptibility of breast cancer in three generations of female offspring, according to the study published online in the journal Breast Cancer Research on Monday. "It is believed that environmental and life-style factors, such as diet, plays a critical role in increasing human breast cancer risk, and so we use animal models to reveal the biological mechanisms responsible for the increase in risk in women and their female progeny," senior author Leena Hilakivi-Clarke, professor of oncology at the Georgetown University, said. The new study revealed a number of genetic changes in the first and third female generations of mice that were fed high-fat diets during pregnancy, including several genes linked in women to increased breast cancer risk, increased resistance to cancer treatment, poor cancer prognosis and impaired anti-cancer immunity.

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